JellyBlue Ingredients: seven actives, seven printed amounts

The largest amount on this panel and the one name here that lands where the research sat. A twelve-week, double-blind, placebo-controlled multicentre study enrolled 105 men aged 50 to 70 with total testosterone under 300 ng/dL and gave them 100 mg or 200 mg a day of a standardised aqueous root extract. Total testosterone rose against placebo at weeks four, eight and twelve in the 200 mg arm.

The 2022 meta-analysis pooled five randomised trials and reported a standardised mean difference of 1.352 with a confidence interval of 0.565 to 2.138, and closed by saying more research is required before clinical use. An earlier randomised trial of the same extract and a six-month trial in men with age-related androgen decline sit behind it.

The caveat is the preparation, not the number. Those trials used a specific standardised aqueous root extract; this label prints an amount and not a specification, so which extract is in the gummy is not something the bottle answers. A published survey measured mercury in tongkat ali preparations bought on the open market in Malaysia, which is the practical argument for a channel with a lot number rather than an anonymous listing.

An Andean brassica root, and one of the few names in this category with a randomised trial in healthy men rather than in a dish. The twelve-week trial gave men aged 21 to 56 either 1,500 mg or 3,000 mg of gelatinised maca a day. Self-reported sexual desire improved from week eight - and serum testosterone and oestradiol did not move, which the authors make a point of.

The systematic review found four randomised trials, two showing an effect and one showing none, and its own verdict is limited evidence.

The distance here is fifteen-fold. This panel prints 100 mg against the smaller of the two trial doses at 1,500 mg. That is the shape of most of this panel and it is set out row by row in the dose section on the home page.

The adaptogen with the deepest recent trial record of the seven, and the one whose evidence is about stress and sleep rather than about vitality. A meta-analysis of twelve trials in 1,002 participants aged 25 to 48 found anxiety fell with a standardised mean difference of -1.55. A separate meta-analysis of five trials in 400 adults found the effect on sleep clearest at 600 mg a day and above, over eight weeks or longer, and a systematic review of nine studies reports a fall in cortisol with no significant adverse effects.

At 100 mg this panel sits a sixth below the threshold the sleep analysis identified. NCCIH's own page sets out the cautions worth knowing: thyroid medicine, sedatives, pregnancy, and the rare liver injury that LiverTox catalogues at full extract doses.

Why it is in a male vitality bottle at all is a fair question. Stress, sleep and energy are the things men describe when they say they feel flat, and ashwagandha is the name in this bottle with trials measuring exactly those.

The name with the longest folk history in this category and the thinnest modern human record. There is no randomised trial of epimedium or icariin in men to quote, and this desk looked rather than assumed.

What exists is chemistry. An isolation study pulled 8-isopentenyl flavonoids out of Epimedium sagittatum and showed they inhibit PDE5A in vitro - the same enzyme family a prescription medicine acts on, in a test tube rather than in a person. That is genuinely interesting chemistry and it is not a result about this gummy.

The one practical consequence: anyone already taking a prescribed PDE5 inhibitor should mention this ingredient to whoever prescribes it. Not because a supplement dose is known to interact, but because nobody has measured whether it does.

The only non-botanical active on the panel, and the first row printed. An amino acid that feeds the nitric oxide pathway.

The meta-analysis pooled ten randomised trials covering 540 men with mild to moderate erectile difficulty and found arginine supplements improved outcomes against placebo, odds ratio 3.37. Every trial in it used between 1,500 mg and 5,000 mg a day. A 2024 network meta-analysis of nutraceuticals studied for the same use places it in a wider ranking.

This panel prints 50 mg, which is thirty times below the smallest dose in that range. It is the largest gap on the label and it is printed here rather than left for a reader to work out. The reason it still belongs in the bottle is that it and beet root work the same pathway from different directions, which is the one piece of genuine formulation logic on this panel.

The seventh name, and the one the seller’s own advertising leaves off. The INSIDE JELLYBLUE graphic shows six tiles and prints SIX NAMED INGREDIENTS across the bottom; the panel on the back of the same bottle prints beet root extract at 50 mg.

It is also the name with the largest and most recent human evidence base of the seven. A 2024 meta-analysis pooled eleven randomised trials covering 349 people with clinical blood pressure at or above 140/90 and found that 200 to 800 mg of nitrate a day, from beetroot juice, lowered clinical systolic pressure by 5.31 mmHg. GRADE certainty was low and the authors say so.

None of that arithmetic transfers to 50 mg of beet root extract in a gummy, and this desk does not pretend it does: the trials used juice, the dose was measured as nitrate, and this panel prints no nitrate figure at all. What is odd is narrower and more interesting than any dose claim - the advertising left off the ingredient with the strongest recent human record on the label.

The proanthocyanidin ingredient, and the second of the two names on this panel with vascular rather than hormonal evidence behind it. A 2022 meta-analysis of nineteen controlled trials found grape seed extract lowered diastolic pressure by 2.20 mmHg and heart rate by 1.25 bpm, while flow-mediated dilation and systolic pressure did not move significantly.

Dose and duration were both named as sources of heterogeneity in that analysis, and 50 mg sits at the very bottom of the range those trials covered. It is the joint-smallest amount on this panel.

In a bottle built around a nitric oxide theme it is a sensible companion to arginine and beet root rather than a headline ingredient, and the panel treats it as one: last row, smallest amount.